Instructors: Jeremy Smith, Hong Guo, Jerome Baudry, Tongye Shen
This course will be a discussion of current themes in molecular biophysics, suitable for motivated senior undergraduates and graduate students in physics, chemistry, computer science and biochemistry. Special emphasis will be on technologies with which Oak Ridge National Laboratory leads the world i.e., neutron scattering and computer simulation. Topics to be covered include an introduction to structural biology, quantum chemistry and force fields, normal modes, molecular dynamics, protein folding, structural change, neutron scattering and diffraction, protein physics and the glass transition, solvation, biomembranes and ion pumps, protein complexes, petascale supercomputing, multiscaling, bioenergy, ligand binding and drug design and enzyme reactions. Examination will take place in the form of graded student presentations during the last 3 or 4 lecture periods.
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Lecture slides from Jeremy Smith:
- Lecture 1 introstructbiol.ppt
- Lecture 1_1 introstructbiol.ppt
- Lecture 1_2 introstructbiol.ppt
- Lecture 1_3 introstructbiol.ppt
- Lecture 2 - QM_forcefields.ppt
- Lecture 3 - MD SIMULATION.ppt
- Lecture 4 - folding and-unboilegg.ppt
- Lecture 5 - enzyme reactions.ppt
- Lecture 5 - structural change.ppt
- Lecture 5B - sidonia2004.ppt
- Lecture 5C - enzyme reactions.ppt
- Lecture 6 - neutron scatt.ppt
- Lecture 7 - dyn transition.ppt
- Lecture 7_2 - vandana.ppt
- Lecture 8 - solvation.ppt
- Lecture 9 - solvation.ppt
- Lecture 9 -gen born.ppt
- Lecture 10 - Zoe.ppt
- Lecture 10 - biomembranes_pumps.ppt
- Lecture 11 - homology mod complexes.ppt
- Lecture 12 - petascale, coarse graining.ppt
- Lecture 13 - bioenergy.ppt
- Lecture 13_2 BESC overview 9-07.ppt
- Lecture 13_3 LDRD20072.ppt
- Lecture 14 - HIV vaccine_cancer diag-drug design.ppt
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